期刊
PHYSICAL REVIEW LETTERS
卷 102, 期 15, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.102.158103
关键词
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资金
- NSF [OCE-0526241, OCE-0744641, DMS-0615919]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1067798, 0966000, 0967510] Funding Source: National Science Foundation
We show that plane parabolic flow in a microfluidic channel causes nonmotile, helically shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign of the shear rate. The drift is in good agreement with a model based on resistive force theory, and separation is efficient (> 80%) and fast (< 2 s). We estimate the effect of Brownian rotational diffusion on chiral separation and show how this method can be extended to separate chiral molecules.
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