期刊
PHYSICAL REVIEW E
卷 85, 期 2, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.85.021909
关键词
-
资金
- NSFC [10974088, 10704033, 10834002, 11174133, 11111140012]
- JiangSu Province [BK2009008]
- Jiangsu higher education institutions
In this work we develop an approach for predicting the tertiary structures of RNA fragments by combining an RNA nucleobase discrete state (RNAnbds) model, a sequential Monte Carlo method, and a statistical potential. The RNAnbds model is designed for optimizing the configuration of nucleobases with respect to their preceding ones along the sequence and their spatial neighbors, in contrast to previous works that focus on RNA backbones. The tests of our approach with the fragments taken from a small RNA pseudoknot and a 23S ribosome RNA show that for short fragments (<10 nucleotides), the root mean square deviations (RMSDs) between the predicted and the experimental ones are generally smaller than 3 A; for slightly longer fragments (10-15 nucleotides), most RMSDs are smaller than 4 A. The comparison of our method with another physics-based predictor with a testing set containing nine loops shows that ours is superior in both accuracy and efficiency. Our approach is useful in facilitating RNA three-dimensional structure prediction as well as loop modeling. It also holds the promise of providing insight into the structural ensembles of RNA loops.
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