期刊
PHYSICAL REVIEW E
卷 78, 期 3, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.78.031904
关键词
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资金
- Alexander von Humboldt Foundation
- Federal Ministry of Education and Research [0313924]
- Network of Excellence BioSim [LSHB-CT-2004-005137]
- Program Radiofizika Russian Academy
- RFBR [RFBR 08-02-00682]
- Ministerio de Educacion y Ciencia (Spain) [ORDEN, I3]
- European Commission [GABA, FP6-NEST, 043309]
We investigate an experimentally feasible synthetic genetic network consisting of two phase repulsively coupled repressilators, which evokes multiple coexisting stable attractors with different features. We perform a bifurcation analysis to determine and classify the dynamical structure of the system. Moreover, some of the dynamical regimes found, such as inhomogeneous steady states and inhomogeneous limit cycles can further be associated with artificial cell differentiation. We also report and characterize the emergence of chaotic dynamics resulting from the intercell coupling.
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