期刊
PHYSICAL REVIEW E
卷 78, 期 6, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.78.060902
关键词
biomechanics; bone; cellular biophysics; DNA; elongation; molecular biophysics; nonlinear dynamical systems; orthopaedics
资金
- Ministry of Health, State of Israel [5210]
Telomeres are DNA repeats protecting chromosomal ends which shorten with each cell division, eventually leading to cessation of cell growth. We present a population mixture model that predicts an exponential decrease in telomere length with time. We analytically solve the dynamics of the telomere length distribution. The model provides an excellent fit to available telomere data and accounts for the previously unexplained observation of telomere elongation following stress and bone marrow transplantation, thereby providing insight into the nature of the telomere clock.
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