期刊
VASCULAR PHARMACOLOGY
卷 71, 期 -, 页码 57-64出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2015.03.003
关键词
Vascular diseases; Atherosclerosis; Akt; Aneurysm
资金
- British Heart Foundation [PG/11/112/29272, RG/08/009/25841, RG/13/14/30314]
- Cambridge NIHR Biomedical Research Centre
- MRC [G0800784, G1000847] Funding Source: UKRI
- Medical Research Council [G0800784, G1000847] Funding Source: researchfish
The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes, including in development and metabolism, as well as cancer and cardiovascular disease. Although Akt signalling has been identified as a promising therapeutic target in cancer, its role in cardiovascular disease is less clear. Importantly, accumulating evidence suggests that the three Akt isoforms exhibit distinct tissue expression profiles, localise to different subcellular compartments, and have unique modes of activation. Consistent with in vitro findings, genetic studies in mice show distinct effects of individual Akt isoforms on the pathophysiology of cardiovascular disease. This review summarises recent studies of individual Akt isoforms in atherosclerosis, vascular remodelling and aneurysm formation, to provide a comprehensive overview of Ala function in vascular disease. (C) 2015 The Authors. Published by Elsevier Inc.
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