In order to annihilate in the early Universe to levels well below the measured dark matter density, asymmetric dark matter must possess large couplings to the standard model. In this paper, we consider effective operators which allow asymmetric dark matter to annihilate into quarks. In addition to a bound from requiring sufficient annihilation, the energy scale of such operators can be constrained by limits from direct detection and monojet searches at colliders. We show that the allowed parameter space for these operators is highly constrained, leading to nontrivial requirements that any model of asymmetric dark matter must satisfy.
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