期刊
VACCINE
卷 33, 期 21, 页码 2457-2462出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.03.091
关键词
Heamagglutinine protein (H); Fusion protein (F); Canine distemper virus; Recombinant Newcastle disease virus; Vaccine
资金
- ministry of science and technology of the people's republic of china [2012ZX10004214]
Canine Distemper Virus (CDV) infects many carnivores and cause several high-mortality disease outbreaks. The current CDV live vaccine cannot be safely used in some exotic species, such as mink and ferret. Here, we generated recombinant lentogenic Newcastle disease virus (NDV) LaSota expressing either envelope glycoproyein, heamagglutinine (H) or fusion protein (F), named as rLa-CDVH and rLa-CDVF, respectively. The feasibility of these recombinant NDVs to serve as live virus-vectored CD vaccine was evaluated in minks. rLa-CDVH induced significant neutralization antibodies (NA) to CDV and provided solid protection against virulent CDV challenge. On the contrast, rLa-CDVF induced much lower NA to CDV and fail to protected mink from virulent CDV challenge. Results suggest that recombinant NDV expressing CDV H is safe and efficient candidate vaccine against CDV in mink, and maybe other host species. (C) 2015 Elsevier Ltd. All rights reserved.
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