期刊
VACCINE
卷 33, 期 35, 页码 4313-4320出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.03.086
关键词
DNA vaccines; Adjuvants; IL-33; CD8 T cells; HIV; LCMV
资金
- National Institutes of Health [U19 AI078675, R01 AI092843, U19 AI109646]
- Inovio Pharmaceuticals
Identifying new molecular adjuvants that elicit effective vaccine-induced CD8(+) T cell immunity may be critical for the elimination of many challenging diseases including Tuberculosis, HIV and cancer. Here, we report that co-administration of molecular adjuvant IL-33 during vaccination enhanced the magnitude and function of antigen (Ag)-specific CD8(+) T cells against a model Ag, LCMV NP target protein. These enhanced responses were characterized by higher frequencies of Ag-specific, polyfunctional CD8(+) T cells exhibiting cytotoxic characteristics. Importantly, these cells were capable of robust expansion upon Ag-specific restimulation in vivo and conferred remarkable protection against a high dose lethal LCMV challenge. In addition, we demonstrate the ability of IL-33 to amplifying the frequency of Ag-specific KLRG1(+) effector CD8(+) T cells. These data show that IL-33 is a promising immunoadjuvant at improving T cell immunity in a vaccine setting and suggest further development and understanding of this molecular adjuvant for strategies against many obstinate infectious diseases and cancer. (C) 2015 Elsevier Ltd. All rights reserved.
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