期刊
VACCINE
卷 33, 期 -, 页码 B21-B28出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2014.12.082
关键词
Cancer; PD-1; CTLA-4; Treg cells; IL-2; mTOR
资金
- National Institutes of Health [R01 AI030048, P01 A1080192, P01 AI056299]
- Irvington Institute Fellowship Program of the Cancer Research Institute
Engagement of CD8T cells is a crucial aspect of immune responses to pathogens and in tumor surveillance. Nonetheless most vaccination strategies with common adjuvants fail to elicit long-term memory CD8T cells. Increased knowledge on the cellular and molecular requirements for CD8T cell activation has unveiled new opportunities to directly modulate CD8T cells to generate optimal responses. During chronic infections and cancer, immunomodulation strategies to enhance T cell responses may be particularly necessary to overcome the immunosuppressive microenvironment. In this review we will discuss blockade of inhibitory receptors; interleukin-2 administration; regulatory T cell modulation; and targeting of mTOR, as means to enhance CD8T cell immunity. (C) 2015 Elsevier Ltd. All rights reserved.
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