期刊
VACCINE
卷 33, 期 31, 页码 3682-3688出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.06.031
关键词
Influenza vaccines; Immunity, Humoral; Models, Statistical; Aged; Adult; Age factors
资金
- National Institute of Allergy And Infectious Diseases of the National Institutes of Health [U01AI089859]
- National Center for Advancing Translational Sciences (CCaTS) [UL1 TR000135]
Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results. (C) 2015 Elsevier Ltd. All rights reserved.
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