期刊
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
卷 23, 期 1, 页码 149-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pmr.2011.11.014
关键词
Muscular dystrophy; DMD; GRMD; Muscle hypertrophy
资金
- NINDS NIH HHS [R01 NS029525] Funding Source: Medline
Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to muscle atrophy. Mdx mice progress through an initial phase of muscle hypertrophy followed by atrophy. Cats have persistent muscle hypertrophy. Hypertrophy in humans has been attributed to deposition of fat and connective tissue (pseudohypertrophy). Increased muscle mass (true hypertrophy) has been documented in animal models. Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy.
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