期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 16, 期 21, 页码 10023-10031出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp55470h
关键词
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资金
- MIUR for funding under the projects PRIN [2010BJ23MN]
- FIRB [RBPR05JH2P_007 ITALNANONET]
- EU (Marie-Curie Reintegration Grant) [SUPRACRYST]
One of the major areas of research in nanomedicine is the design of drug delivery systems with remotely controllable release of the drug. Despite the enormous progress in the field, this aspect still poses a challenge, especially in terms of selectivity and possible harmful interactions with biological components other than the target. We report an innovative approach for the controlled release of DNA, based on clusters of core-shell magnetic nanoparticles. The primary nanoparticles are functionalized with a single-stranded oligonucleotide, whose pairing with a half-complementary strand in solution induces clusterization. The application of a low frequency (6 KHz) alternating magnetic field induces DNA melting with the release of the single strand that induces clusterization. The possibility of steering and localizing the magnetic nanoparticles, and magnetically actuating the DNA release discloses new perspectives in the field of nucleic-acid based therapy.
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