期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 16, 期 48, 页码 27037-27042出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cp04260c
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资金
- NIH [RO1EB12003, R15AG038977]
- NSF [CBET-1264608]
- INFOR grant from Texas Christian University
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1264608] Funding Source: National Science Foundation
Fluorescence properties of a novel homodimeric BODIPY dye rotor for Fluorescence Lifetime Imaging Microscopy (FLIM) are reported. Steady state and time resolved fluorescence measurements established the viscosity dependent behaviour in vitro. Homodimeric BODIPY embedded in different membrane mimicking lipid vesicles (DPPC, POPC and POPC plus cholesterol) is demonstrated to be a viable sensor for fluorescence lifetime based viscosity measurements. Moreover, SKOV3 cells readily endocytosed the dye, which accumulated in membranous structures inside the cytoplasm thereby allowing viscosity mapping of internal cell components.
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