期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 15, 期 27, 页码 11454-11460出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp50916h
关键词
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资金
- Japan Society for the Promotion of Science (JSPS) [23560925]
- Innovation School program by the National Institute of Advanced Industrial Science and Technology
- Grants-in-Aid for Scientific Research [23560925] Funding Source: KAKEN
We investigated the drug releasing behavior of a novel nanocarrier system, utilizing a peptide to act as a nanogate to the mesopore, on a mesoporous silica nanoparticle. The surface peptide on mesoporous silica displayed pH-dependant mesopore cap-uncap switching behavior, enabled by the reversible beta-sheet-to-random coil conformational transition resulting from slight pH changes between 8.0 and 6.0. The peptide adopted a beta-sheet structure under weakly basic conditions (pH 8.0) and a random coil conformation under weakly acidic conditions (pH 6.0). We demonstrated the pH-dependant regulation of the material's drug release property by the reversible conformational transition of the surface peptide. Under basic pH conditions, the drug release from the nanocarrier was significantly inhibited. However, under acidic pH conditions, the drug in the mesopore was gradually released.
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