期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 15, 期 38, 页码 15727-15733出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp44227f
关键词
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资金
- National Natural Science Foundation of China [11074053, 31170802]
Gold nanorods (AuNRs) were conjugated with chlorin e6 (Ce6), a commonly used photosensitizer, to form AuNRs-Ce6 by electrostatic binding. Due to the strong surface plasmon resonance coupling, the fluorescence of conjugated Ce6 was enhanced 3-fold and the production of singlet oxygen was increased 1.4-fold. AuNRs-Ce6 were taken up by the HeLa and KB cell lines more easily than free Ce6, enhancing the intracellular delivery of Ce6. The increased cellular amount of Ce6 leads to a 3-fold more efficient photodynamic killing of these two cell lines. This demonstrates the potential of this approach to improve photodynamic detection and therapy of cancers.
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