期刊
ARCHIVES OF TOXICOLOGY
卷 89, 期 12, 页码 2197-2205出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-015-1633-3
关键词
Cisplatin; Nephrotoxicity; Apoptosis; Kidney; DNA damage; P53
类别
资金
- National Natural Science Foundation of China [81430017]
- National Basic Research Program of China 973 Program [2012CB517601]
- National Institutes of Health and Department of Veterans Administration of USA
Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.
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