期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 46, 期 4, 页码 452-459出版社
WILEY
DOI: 10.1002/uog.14920
关键词
aortic isthmus; Doppler; ductus venosus; intrauterine growth restriction; middle cerebral artery; myocardial performance index
资金
- Fondo de Investigacion Sanitaria (Spain) [PI/060347]
- Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)
- Thrasher Research Fund (Salt Lake City, USA)
- Mexican National Council for Science and Technology (CONACyT)
Objective To estimate the value of gestational age at birth and fetal Doppler parameters in predicting the risk of neonatal cranial abnormalities in intrauterine growth-restricted (IUGR) fetuses born between 28 and 34 weeks' gestation. Methods Fetal Doppler parameters including umbilical artery (UA), middle cerebral artery (MCA), aortic isthmus, ductus venosus and myocardial performance index were evaluated in a cohort of 90 IUGR fetuses with abnormal UA Doppler delivered between 28 and 34 weeks' gestation and in 90 control fetuses matched for gestational age. The value of gestational age at birth and fetal Doppler parameters in predicting the risk of ultrasound-detected cranial abnormalities (CUA), including intraventricular hemorrhage, periventricular leukomalacia and basal ganglia lesions, was analyzed. Results Overall, IUGR fetuses showed a significantly higher incidence of CUA than did control fetuses (40.0% vs 12.2%, respectively; P< 0.001). Within the IUGR group, all predictive variables were associated individually with the risk of CUA, but fetal Doppler parameters rather than gestational age at birth were identified as the best predictor. MCA Doppler distinguished two groups with different degrees of risk of CUA (48.5% vs 13.6%, respectively; P< 0.01). In the subgroup with MCA vasodilation, presence of aortic isthmus retrograde net blood flow, compared to antegrade flow, allowed identification of a subgroup of cases with the highest risk of CUA (66.7% vs 38.6%, respectively; P< 0.05). Conclusion Evaluation of fetal Doppler parameters, rather than gestational age at birth, allows identification of IUGR preterm fetuses at risk of neonatal brain abnormalities. Copyright (C) 2015 ISUOG. Published by John Wiley & Sons Ltd.
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