期刊
PHYSICAL BIOLOGY
卷 11, 期 4, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1478-3975/11/4/046006
关键词
ion channels; excitable cells; mechanical properties of membranes; spike propagation; modeling
资金
- LOEWE program of the State of Hesse
Ion channels of excitable membranes are known to be sensitive to various kinds of stimuli, but the case of simultaneous occurrence of different stimuli is poorly understood. Here, we theoretically analyze the influence of membrane tension on the dynamics of voltage-gated ion channels of excitable membranes. To do so, we develop a modification of the well-known Hodgkin-Huxley model to study numerically the spike generation and propagation in a single and two coupled excitable cells. We find that these cells can use membrane tension to trigger sub-threshold spike propagation, to suppress spike propagation and to alter the intensity of the signal transmission. These effects indicate that cells could use membrane tension to regulate cell-to-cell communication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据