期刊
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
卷 209, 期 5, 页码 892-899出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pssa.201100715
关键词
biosensor; finite element analysis; molecular imprinting; quartz crystal microbalance
资金
- Hasselt University
- Life Science Initiative of the Province Limburg
Molecularly imprinted polymers (MIPs) offer a huge potential in the development of cheap small-scale disposable biomimetic sensors. They are suited for a wide variety of biological targets and are compatible with many different measurement techniques such as gravimetric sensing and impedance spectroscopy. One potential sensor platform for MIP-based biosensors is the quartz crystal microbalance (QCM). A 4-channel MIP/non-imprinted polymer (NIP) coated QCM biosensor array was developed on a single piece of quartz crystal. To study cross-channel frequency coupling of the resonance modes, a simulation of crystal designs using finite element analysis (FEA) modeling was created. Based on these simulations and using reactive ion etching (RIE) to create mesa-like structures on the crystal surface, crosstalk can be severely reduced. The improved functionality compared to the traditional QCMs was demonstrated by employing these mesa-type multichannel QCM (MQCM) crystals as an L-nicotine biosensor platform. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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