期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 41, 期 9, 页码 2420-2434出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.04.025
关键词
Thermal ablation monitoring; Passive acoustic mapping; Cavitation; Receiver operating characteristic curve; Ultrasound-guided ablation
资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH) [R21EB008483]
- National Heart, Lung, and Blood Institute of the NIH [R01HL059586, R01HL074002, F32HL104916]
- National Cancer Institute of the NIH [R01CA158439]
Passive cavitation imaging provides spatially resolved monitoring of cavitation emissions. However, the diffraction limit of a linear imaging array results in relatively poor range resolution. Poor range resolution has limited prior analyses of the spatial specificity and sensitivity of passive cavitation imaging in predicting thermal lesion formation. In this study, this limitation is overcome by orienting a linear array orthogonal to the high-intensity focused ultrasound propagation direction and performing passive imaging. Fourteen lesions were formed in ex vivo bovine liver samples as a result of 1.1-MHz continuous-wave ultrasound exposure. The lesions were classified as focal, tadpole or pre-focal based on their shape and location. Passive cavitation images were beam-formed from emissions at the fundamental, harmonic, ultraharmonic and inharmonic frequencies with an established algorithm. Using the area under a receiver operating characteristic curve (AUROC), fundamental, harmonic and ultraharmonic emissions were found to be significant predictors of lesion formation for all lesion types. For both harmonic and ultraharmonic emissions, pre-focal lesions were classified most successfully (AUROC values of 0.87 and 0.88, respectively), followed by tadpole lesions (AUROC values of 0.77 and 0.64, respectively) and focal lesions (AUROC values of 0.65 and 0.60, respectively). (C) 2015 World Federation for Ultrasound in Medicine & Biology.
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