期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 41, 期 5, 页码 1432-1445出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.01.004
关键词
Ultrasound contrast agent; Lipid-coated microbubbles; High-speed optical imaging; Subharmonic; Second harmonic; Non-linear; Elasticity; Viscosity; Stability
资金
- NanoNextNL
- Government of the Netherlands
- Center for Translational Molecular Medicine (CTMM)
- Netherlands Heart Foundation (PARISk)
For successful in vivo contrast-enhanced ultrasound imaging (CEUS) and ultrasound molecular imaging, detailed knowledge of stability and acoustical properties of the microbubbles is essential. Here, we compare these aspects of lipid-coated microbubbles that have either 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as their main lipid; the other components were identical. The microbubbles were investigated in vitro over the frequency range 1-4 MHz at pressures between 10 and 100 kPa, and their response to the applied ultrasound was recorded using ultrahigh-speed imaging (15 Mfps). Relative to DPPC-coated microbubbles, DSPC-coated microbubbles had (i) higher acoustical stability; (ii) higher shell elasticity as derived using the Marmottant model (DSPC: 0.26 +/- 0.13 N/m, DPPC: 0.06 +/- 0.06 N/m); (iii) pressure amplitudes twice as high at the second harmonic frequency; and (iv) a smaller amount of microbubbles that responded at the subharmonic frequency. Because of their higher acoustical stability and higher non-linear response, DSPC-coated microbubbles may be more suitable for contrast-enhanced ultrasound. (C) 2015 World Federation for Ultrasound in Medicine & Biology.
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