期刊
ULTRASONICS SONOCHEMISTRY
卷 24, 期 -, 页码 1-7出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2014.12.006
关键词
Ultrasonic irradiation; 2-Amino-3-cyano-4H-pyrans; Multi-component reactions; Heteroaryl aldehydes; Malononitrile; Active methylene compounds
资金
- VGST, Dept. of IT, BT and Science & Technology, Government of Karnataka for the CESEM Award [24 (2010-2011)]
An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives. (C) 2014 Elsevier B.V. All rights reserved.
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