Fundamental study for development magnetic drug delivery system

Side-effects and lowering effects by diffusion of drugs such as anticancer agents is one of the serious issues in medication. To solve this problem, it is necessary to control the drugs quantitatively. spatially and temporally within the human body. Magnetic drug delivery system (MDDS) is one of the technologies to make it possible, in which the ferromagnetic drug injected into the blood vessel is conducted to diseased part by external magnetic force. As a fundamental experiment, the accumulation experiment using ferromagnetic particles were performed with simulated capillary vessels composed of glass beads channels in this work. Additionally, accumulation calculation of ferromagnetic particles was conducted to check the validity of accumulation experiment. From these result, the 2D distribution of particle accumulation in the experiment corresponded with that of particle accumulation in the calculation. It was suggested that the proper position of magnet should be changed according to the depth of diseased part. (C) 2009 Elsevier B.V. All rights reserved.