期刊
ULTRASCHALL IN DER MEDIZIN
卷 36, 期 6, 页码 581-589出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0041-107831
关键词
liver fibrosis; liver cirrhosis; B-mode ultrasound; ARFI elastography; mini-laparascopy
资金
- GFGB (Gesellschaft fur Gastroenterologie in Bayern e.V.)
Purpose: Ultrasound is awell-established noninvasive test for assessing patients with liver disease. This study aims to prospectively compare ultrasound to the new technique elastography (ARFI) for the assessment of liver fibrosis/cirrhosis. Materials and Methods: High-frequency B-mode ultrasound (liver surface/vein irregularity, liver homogeneity, spleen size), ARFI quantification, mini-laparoscopic liver evaluation including biopsy were prospectively obtained in compensated patients scheduled for liver biopsy. For the diagnosis of cirrhosis, a combined gold standard (cirrhosis at histology and/or at macroscopic liver evaluation) was used. Results: Out of 157 patients, 35 patients were diagnosed cirrhotic. Ultrasound (combination of liver vein and/or surface irregularity) showed no significant difference compared to ARFI quantification for the diagnosis of significant liver fibrosis (Ishak > = 3) and cirrhosis. Diagnosis of cirrhosis had a sensitivity/specificity/PPV/NPV of 83 %(+/- 12)/82% (+/- 7)/57%(+/- 14)/94 %(+/- 4), respectively, with ultrasound and 86 %(+/- 12)/81%(+/- 7)/57 %(+/- 13)/95 % (+/- 4), respectively, with ARFI quantification. The sensitivity/specificity/PPV/NPV for the detection of significant fibrosis were 68 %(+/- 13)/86%(+/- 7)/71%(+/- 13)/84%(+/- 7), respectively, for ultrasound and 70 %(+/- 12)/84%(+/- 7)/69%(+/- 12)/84 %(+/- 7), respectively, for ARFI quantification. Conclusion: ARFI elastography and high-frequency B-mode ultrasound show similar and good results for the diagnosis of compensated liver cirrhosis and high-grade fibrosis. A key benefit of both methods is the high NPV suggesting them as noninvasive exclusion tests.
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