Photodynamic Modulation of Wound Healing: A Review of Human and Animal Studies

Objective: The purpose of this study was to review studies of photodynamic therapy (PDT) on wound healing and cells in vitro, to assess the effects of such therapy. Background data: PDT is used to treat tumors. When activated by light of a specific wavelength, the photosensitizer produces reactive oxygen species (ROS) that kill tumor cells. Low levels of ROS may induce cellular proliferation. Methods: Research articles investigating PDT on wound healing and cells in vitro published up to August 2010 were retrieved from library sources, PubMed and Medline databases, reference lists of articles, and searches of relevant journals. Results: The studies indicated that use of various photosensitizers combined with laser irradiation led to improved wound outcomes. For most in vitro studies, there was a decrease in cell growth or viability. Conclusions: PDT improved healing outcomes in several animal wound models, but mainly had an inhibitory effect on cells in vitro. These findings strongly support PDT for wound healing.