期刊
TURKISH JOURNAL OF GASTROENTEROLOGY
卷 25, 期 -, 页码 167-175出版社
AVES
DOI: 10.5152/tjg.2014.5121
关键词
Non-alcoholic steatohepatitis; infliximab; adalimumab; pentoxifylline; rats
Background/Aims: Non-alcoholic steatohepatitis (NASH) lacks effective medical treatment. Since tumor necrosis factor alpha (TNF-alpha) plays an important role in NASH pathogenesis, we aimed to investigate drugs affecting TNF-a as possible treatment options during the development of NASH. Materials and Methods: A total of 35 rats were divided into five groupsand evaluated over a 6week period. One group received a normal diet alone or in combination with the administration of infliximab, adalimumab or pentoxifylline Results: NASH was successfully established in the MCD diet group. Levels of TNF-a were effectively suppressed in the three groups that received anti-TNF agents. No statistically significant differences were observed between the three agents in terms of the histological NASH score. Conclusion: Our study showed that the anti-TNF agents infliximab, adalimumab, and pentoxifylline effectively suppress TNF-alpha. Although these drugs did not prevent the development of NASH, they were able to slightly reverse the NASH histopathology score and positively affect liver function tests
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据