期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 90, 期 3, 页码 659-666出版社
WILEY
DOI: 10.1111/php.12212
关键词
-
资金
- National Research Foundation of Korea [R11-2008-0061852, K20904000004-12A0500-00410]
- National Research Foundation of Korea - Ministry of Education, Science, and Technology [2012035286]
- Agency for Defense Development through Chemical and Biological Defense Research Center
- Development of Characterization Techniques for Nano-materials Safety Project of KRCF
- National Research Foundation (NRF) - Korea Government (MEST) [2011-0017435]
- Korea government [MSIP] [20090083525]
Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60Wcm(-2)) for 5min after treatment with the AuNR-PEG-GO nanocomposites for 24h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据