期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 87, 期 4, 页码 862-866出版社
WILEY
DOI: 10.1111/j.1751-1097.2011.00922.x
关键词
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资金
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 33919]
- Danish National Research Foundation
- Coimbra Group
- CONICET
Pterins, heterocyclic compounds widespread in biological systems, participate in relevant biological processes and are able to act as photosensitizers. In the present study, we ascertained that 2-aminopteridin-4(3H)-one, abbreviated as Ptr, is readily incorporated into and/or onto cervical cancer cells (HeLa) and that these cells die upon UV-A irradiation of Ptr. Cell death was assessed using two tests: (1) the Rhodamine 123 fluorescence assay for mitochondrial viability and (2) the Trypan Blue assay for membrane integrity. The data suggest that, for Ptr-dependent photoinitiated cell death, events related to mitochondrial failure precede those associated with the failure of the cell membrane.
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