期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 11, 期 7, 页码 1156-1163出版社
SPRINGERNATURE
DOI: 10.1039/c2pp05411f
关键词
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资金
- German-Egyptian Academic Exchange program (DAAD)
- Institute for Laser technologies in Medicine (ILM), Ulm University
Photodynamic therapy (PDT) has been the subject of several clinical studies. Evidence to date suggests that direct cell death may involve apoptosis. T-24 cells (bladder cancer cells, ATCC-Nr. HTB-4) were subjected to PDT with aluminum phthalocyanine tetrasulfonate chloride (AlS4Pc-Cl) and red laser light at 670 nm. Morphological changes after PDT were visualized under confocal microscopy. Raman microspectroscopy is considered as one of the newly established methods used for the detection of cytochrome c as an apoptotic marker. Results showed that PDT treated T-24 cells seem to undergo apoptosis after irradiation with 3 J cm(-2). Cytochrome c could not be detected from cells incubated with AlS4Pc-Cl using Raman spectroscopy whereas AlS4Pc-Cl seems to interfere with the Raman spectrum of cytochrome c.
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