期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 11, 期 3, 页码 556-563出版社
SPRINGERNATURE
DOI: 10.1039/c2pp05320a
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/C50446X/1]
- Engineering and Physical Sciences Research Council
- University of Birmingham
- CNRS
- Birmingham Science City: Innovative Uses for Advanced Materials in the Modern World (West Midlands Centre for Advanced Materials)
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- Biotechnology and Biological Sciences Research Council [BB/C50446X/1] Funding Source: researchfish
The synthesis of photolabile tyrosine derivatives protected on the phenolic oxygen by the alpha-carboxy-6-nitroveratryl (alpha CNV) protecting group is described. The compounds undergo rapid photolysis at wavelengths longer than 300 nm to liberate the corresponding phenol in excellent yield (quantum yield for the deprotection of tyrosine = 0.19). Further protection of caged tyrosine is possible, yielding N-Fmoc protected derivatives suitable for direct incorporation of caged tyrosine in solid-phase peptide synthesis.
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