期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 7, 期 1, 页码 84-97出版社
SPRINGERNATURE
DOI: 10.1039/b711398f
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资金
- Medical Research Council [MC_U117532185, MC_U117533887] Funding Source: researchfish
- MRC [MC_U117533887, MC_U117532185] Funding Source: UKRI
Photolysis of alpha-carboxy-2-nitrobenzyl (CNB) caged compounds, studied here by time-resolved IR and UV spectroscopy, involves at least two pathways. In one, a conventional 2-nitrobenzyl type rearrangement takes place to release the photoprotected species via rapid decay of an aci-nitro intermediate. The alpha-carboxylate moiety of the CNB group is retained and the final by-product from this pathway is 2-nitrosophenylglyoxylate. Direct measurements of product formation confirmed that release via this pathway is faster for CNB-caged compounds than for related caged compounds without an a-carboxylate substituent and a rationale for the faster release rate is proposed. In a second pathway, photodecarboxylation of the starting material occurs: this pathway leads only to a slow, minor release of the photoprotected species. The extent to which the latter pathway contributes is affected by the nature of buffer salts in the irradiated solution. It was more prominent in an amine-based buffer (MOPS) than in phosphate buffer.
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