期刊
TURKISH JOURNAL OF CHEMISTRY
卷 39, 期 5, 页码 1102-1113出版社
SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK
DOI: 10.3906/kim-1504-12
关键词
5-Aminopyrazole; pyrazolopyrimidines; ferroceny1-2-carboxaldehyde; Schiff bases; antitumor activity
The reaction of 5-amino 3 (4 methoxyphenylamino)-N-aryl-1H-pyrazole-4-carboxamides 1a-c with ethyl acetoacetate 2 and 2-(4-fluorobenzylidene)malononitrile 6 yielded pyrazolo[1,5-a]pyrimidines 5a-c and 9a-c, respectively. On the other hand, Schiff bases 11a-f were obtained upon treatment of carboxamides 1a-c with some selected aldehydes 10a and b. The newly synthesized compounds were characterized and confirmed by analytical and spectroscopic data (IR, MS, H-1 NMR, and C-13 NMR). Pyrazolo[1,5-a]pyrimidines 5a-c and 9a-c and Schiff bases 11b-f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure activity relationship was discussed.
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