期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 369, 期 1638, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2013.0106
关键词
tumour; ion channel; Kv1.3; KCa3.1; Ca2+-release-activated Ca2+; immunosuppressive network
类别
资金
- Hungarian Social Renewal Operational Program [TAMOP-4.2.2-A-11/1/KONV-2012-0025, TAMOP-4.2.2/B-10/1-2010-0024]
- Hungarian Scientific Research Fund [K75904, CK 78179, NK101337]
- Ministerio de Economia y Competitividad, Spain [BFU2011-23268, CSD2008-00005]
- US National Institutes of Health [NS073712]
- US Department of Defense [BC096018]
The outcome of a malignant disease depends on the efficacy of the immune system to destroy cancer cells. Key steps in this process, for example the generation of a proper Ca2+ signal induced by recognition of a specific antigen, are regulated by various ion channel including voltage-gated Kv1.3 and Ca2+-activated KCa3.1 K+ channels, and the interplay between Orai and STIM to produce the Ca2+-release-activated Ca2+ (CRAC) current required for T-cell proliferation and function. Understanding the immune cell subset-specific expression of ion channels along with their particular function in a given cell type, and the role of cancer tissue-dependent factors in the regulation of operation of these ion channels are emerging questions to be addressed in the fight against cancer disease. Answering these questions might lead to a better understanding of the immunosuppression phenomenon in cancer tissue and the development of drugs aimed at skewing the distribution of immune cell types towards killing of the tumour cells.
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