期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 369, 期 1633, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2013.0288
关键词
synaptic plasticity; memory; long-term potentiation; engram; initial consolidation; dopamine
类别
资金
- European Research Council [268800]
- Mitsubishi Tanabe Pharma Corporation
- UK Medical Research Council
- Medical Research Council [1177572, 1101577] Funding Source: researchfish
- European Research Council (ERC) [268800] Funding Source: European Research Council (ERC)
The synaptic plasticity and memory hypothesis asserts that activity-dependent synaptic plasticity is induced at appropriate synapses during memory formation and is both necessary and sufficient for the encoding and trace storage of the type of memory mediated by the brain area in which it is observed. Criteria for establishing the necessity and sufficiency of such plasticity in mediating trace storage have been identified and are here reviewed in relation to new work using some of the diverse techniques of contemporary neuroscience. Evidence derived using optical imaging, molecular-genetic and optogenetic techniques in conjunction with appropriate behavioural analyses continues to offer support for the idea that changing the strength of connections between neurons is one of the major mechanisms by which engrams are stored in the brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据