期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 369, 期 1633, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2013.0146
关键词
chronic pain; anterior cingulate cortex; long-term potentiation; analgesia; adenylyl cyclase; cyclic adenosine monophosphate
类别
资金
- EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health
- Canada Research Chair
- NSEC [402555]
- CIHR
- World-Class University (WCU) programme of the Ministry of Education, Science and Technology in Korea through KOSEF [R32-10142]
Glutamate is the primary excitatory transmitter of sensory transmission and perception in the central nervous system. Painful or noxious stimuli from the periphery 'teach' humans and animals to avoid potentially dangerous objects or environments, whereas tissue injury itself causes unnecessary chronic pain that can even last for long periods of time. Conventional pain medicines often fail to control chronic pain. Recent neurobiological studies suggest that synaptic plasticity taking place in sensory pathways, from spinal dorsal horn to cortical areas, contributes to chronic pain. Injuries trigger long-term potentiation of synaptic transmission in the spinal cord dorsal horn and anterior cingulate cortex, and such persistent potentiation does not require continuous neuronal activity from the periphery. At the synaptic level, potentiation of excitatory transmission caused by injuries may be mediated by the enhancement of glutamate release from presynaptic terminals and potentiated postsynaptic responses of AMPA receptors. Preventing, 'erasing' or reducing such potentiation may serve as a new mechanism to inhibit chronic pain in patients in the future.
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