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RNA (2011)
A 1.9 Å Crystal Structure of the HDV Ribozyme Precleavage Suggests both Lewis Acid and General Acid Mechanisms Contribute to Phosphodiester Cleavage
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Formation of an active site in trans by interaction of two complete Varkud Satellite ribozymes
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RNA (2009)
Self-Sustained Replication of an RNA Enzyme
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Functional identification of ligands for a catalytic metal ion in group I introns
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An uncharged amine in the transition state of the ribosornal peptidyl transfer reaction
David A. Kingery et al.
CHEMISTRY & BIOLOGY (2008)
Structure and function of an RNase H domain at the heart of the spliceosome
Vladimir Pena et al.
EMBO JOURNAL (2008)
Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme
Hong Xiao et al.
NATURE (2008)
A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA
Monika Martick et al.
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Structural elucidation of a PRP8 core domain from the heart of the spliceosome
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Crystal structure of a self-spliced group II intron
Navtej Toor et al.
SCIENCE (2008)
The complete VS ribozyme in solution studied by small-angle X-ray scattering
Jan Lipfert et al.
STRUCTURE (2008)
Essential role of an active-site guanine in glmS ribozyme catalysis
Daniel J. Klein et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution
Sarah B. Voytek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A second divalent metal ion in the group II intron reaction center
Peter M. Gordon et al.
CHEMISTRY & BIOLOGY (2007)
A guanine nucleobase important for catalysis by the VS ribozyme
Timothy J. Wilson et al.
EMBO JOURNAL (2007)
Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme
M. Duane Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The structural basis of ribozyme-catalyzed RNA assembly
Michael P. Robertson et al.
SCIENCE (2007)
Structural investigation of the GlmS ribozyme bound to its catalytic cofactor
Jesse C. Cochrane et al.
CHEMISTRY & BIOLOGY (2007)
Bacterial RNase P: a new view of an ancient enzyme
Alexei V. Kazantsev et al.
NATURE REVIEWS MICROBIOLOGY (2006)
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate
Daniel J. Klein et al.
SCIENCE (2006)
A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene
Kourosh Salehi-Ashtiani et al.
SCIENCE (2006)
Tertiary contacts distant from the active site prime a ribozyme for catalysis
Monika Martick et al.
CELL (2006)
Nucleobase catalysis in the hairpin ribozyme
Timothy J. Wilson et al.
RNA (2006)
Making and breaking nucleic acids:: Two-Mg2+-ion catalysis and substrate specificity
W Yang et al.
MOLECULAR CELL (2006)
Structural insights into the roles of water and the 2′ hydroxyl of the P site tRNA in the peptidyl transferase reaction
TM Schmeing et al.
MOLECULAR CELL (2005)
Structural evidence for a two-metal-ion mechanism of group I intron splicing
MR Stahley et al.
SCIENCE (2005)
Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
M Nowotny et al.
CELL (2005)
General acid catalysis by the hepatitis delta virus ribozyme
SR Das et al.
NATURE CHEMICAL BIOLOGY (2005)
Model for general acid-base catalysis by the hammerhead ribozyme: pH-activity relationships of G8 and G12 variants at the putative active site
J Han et al.
BIOCHEMISTRY (2005)
Nucleobase participation in ribozyme catalysis
ZY Zhao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation
A Serganov et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Control of gene expression by a natural metabolite-responsive ribozyme
WC Winkler et al.
NATURE (2004)
Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme
R Zamel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Fast cleavage kinetics of a natural hammerhead ribozyme
MD Canny et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Crystal structure of a self-splicing group I intron with both exons
PL Adams et al.
NATURE (2004)
Substrate-assisted catalysis of peptide bond formation by the ribosome
JS Weinger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
The ribosome as an entropy trap
A Sievers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A conformational switch controls hepatitis delta virus ribozyme catalysis
AL Ke et al.
NATURE (2004)
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
M Mandal et al.
CELL (2003)
Ionization of a critical adenosine residue in the Neurospora Varkud Satellite ribozyme active site
FD Jones et al.
BIOCHEMISTRY (2003)
Transition state stabilization by a catalytic RNA
PB Rupert et al.
SCIENCE (2002)
Functional group requirements in the probable active site of the VS ribozyme
DA Lafontaine et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
A self-replicating ligase ribozyme
N Paul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
4-thio-U cross-linking identifies the active site of the VS ribozyme
SL Hiley et al.
EMBO JOURNAL (2002)
The global structure of the VS ribozyme
DA Lafontaine et al.
EMBO JOURNAL (2002)
Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis
PM Gordon et al.
NATURE STRUCTURAL BIOLOGY (2001)
The A730 loop is an important component of the active site of the VS ribozyme
DA Lafontaine et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension
WK Johnston et al.
SCIENCE (2001)
Novel RNA catalysts for the Michael reaction
G Sengle et al.
CHEMISTRY & BIOLOGY (2001)
Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis
PB Rupert et al.
NATURE (2001)
Optimization and optimality of a short ribozyme ligase that joins non-Watson-Crick base pairings
MP Robertson et al.
RNA (2001)
Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction
DA Lafontaine et al.
EMBO JOURNAL (2001)
The structural basis of ribosome activity in peptide bond synthesis
P Nissen et al.
SCIENCE (2000)
Design and optimization of effector-activated ribozyme ligases
Michael P. Robertson et al.
NUCLEIC ACIDS RESEARCH (2000)
General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
S Nakano et al.
SCIENCE (2000)
Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: Extending the parallels between the spliceosome and group II introns
PM Gordon et al.
RNA (2000)