期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 366, 期 1575, 页码 2266-2273出版社
ROYAL SOC
DOI: 10.1098/rstb.2011.0042
关键词
reprogramming; germ cells; chromatin; DNA demethylation
类别
资金
- Medical Research Council
- MRC [MC_U120092689] Funding Source: UKRI
- Medical Research Council [MC_U120092689] Funding Source: researchfish
Epigenetic reprogramming in the germline provides a developmental model to study the erasure of epigenetic memory as it occurs naturally in vivo in the course of normal embryonic development. Our data show that germline reprogramming comprises both active DNA demethylation and extensive chromatin remodelling that are mechanistically linked through the activation of the base excision DNA repair pathway involved in the DNA demethylation process. The observed molecular hallmarks of the germline reprogramming exhibit intriguing similarities to other dedifferentiation or regeneration systems, pointing towards the existence of unifying molecular pathways underlying cell fate reversal. Elucidation of molecular processes involved in the resetting of epigenetic information in vivo will thus add to our ability to manipulate cell fate and to restore pluripotency in in vitro settings.
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