期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 364, 期 1521, 页码 1255-1262出版社
ROYAL SOC
DOI: 10.1098/rstb.2008.0320
关键词
long-term memory; anticipation; storage; consolidations; plasticity; metaplasticity
类别
资金
- Israeli Science Foundation (ISF)
- US-Israel Binational Science Foundation (BSF)
- Nella and Leon Benoziyo Center for Neurological Diseases
- Minerva Foundation
Although the faculty of memory holds information about the past, it is mostly about the present and the future, because it permits adaptive responses to ongoing events as well as to events yet to come. Since many elements in the future are uncertain, the plasticity machinery that encodes memories in the brain has to operate under the assumption that stored information is likely to require fast and recurrent updating. This assumption is reflected at multiple levels of the brain, including the synaptic and the cellular level. Recent findings cast new light on how combinations of plasticity and metaplasticity mechanisms could permit the brain to balance over time between stability and plasticity of the information stored.
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