期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 363, 期 1507, 页码 3137-3146出版社
ROYAL SOC
DOI: 10.1098/rstb.2008.0093
关键词
sensitization; dopamine; habits; cocaine; amphetamine; motivation
类别
资金
- NIDA NIH HHS [R01 DA015188] Funding Source: Medline
- NIMH NIH HHS [R01 MH063649] Funding Source: Medline
We present a brief overview of the incentive sensitization theory of addiction. This posits that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli. If rendered hypersensitive, these systems cause pathological incentive motivation ('wanting') for drugs. We address some current questions including: what is the role of learning in incentive sensitization and addiction? Does incentive sensitization occur in human addicts? Is the development of addiction-like behaviour in animals associated with sensitization? What is the best way to model addiction symptoms using animal models? And, finally, what are the roles of affective pleasure or withdrawal in addiction?.
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