期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 363, 期 1503, 页码 2519-2527出版社
ROYAL SOC
DOI: 10.1098/rstb.2008.0037
关键词
antisocial behaviour; genetic; environmental risk; callous-unemotional
类别
资金
- Medical Research Council [G0401170] Funding Source: Medline
- Department of Health [MRD 12-37] Funding Source: Medline
- MRC [G0401170] Funding Source: UKRI
- Medical Research Council [G0401170] Funding Source: researchfish
This paper will broadly review the currently available twin and adoption data on antisocial behaviour ( AB). It is argued that quantitative genetic research can make a significant contribution to further the understanding of how AB develops. Genetically informative study designs are particularly useful for investigating several important questions such as whether: the heritability estimates vary as a function of assessment method or gender; the relative importance of genetic and environmental influences varies for different types of AB; the environmental risk factors are truly environmental; and genetic vulnerability influences susceptibility to environmental risk. While the current data are not yet directly translatable for prevention and treatment programmes, quantitative genetic research has concrete translational potential. Quantitative genetic research can supplement neuroscience research in informing about different subtypes of AB, such as AB coupled with callous - unemotional traits. Quantitative genetic research is also important in advancing the understanding of the mechanisms by which environmental risk operates.
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