期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
卷 370, 期 1973, 页码 3924-3949出版社
ROYAL SOC
DOI: 10.1098/rsta.2011.0049
关键词
regenerative medicine; stem cells; manufacturing; automation; characterization
资金
- Engineering and Physical Sciences Research Council [EP/H028277/1] Funding Source: researchfish
- EPSRC [EP/H028277/1] Funding Source: UKRI
Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.
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