期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
卷 367, 期 1891, 页码 1145-1161出版社
ROYAL SOC
DOI: 10.1098/rsta.2008.0255
关键词
absence epilepsy; spike wave; human electroencephalography; mathematical modelling; bifurcation; continuation
资金
- Engineering and Physical Sciences Research Council [EP/D068436/1] Funding Source: researchfish
- EPSRC [EP/D068436/1] Funding Source: UKRI
In this paper, we introduce a modi. cation of a mean-field model used to describe the brain's electrical activity as recorded via electroencephalography (EEG). The focus of the present study is to understand the mechanisms giving rise to the dynamics observed during absence epilepsy, one of the classical generalized syndromes. A systematic study of the data from a number of different subjects with absence epilepsy demonstrates a wide variety of dynamical phenomena in the recorded EEG. In addition to the classical spike and wave activity, there may be polyspike and wave, wave spike or even no discernible spike-wave onset during seizure events. The model we introduce is able to capture all of these different phenomena and we describe the bifurcations giving rise to these different types of seizure activity. We argue that such a model may provide a useful clinical tool for classifying different subclasses of absence epilepsy.
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