期刊
TUMOR BIOLOGY
卷 36, 期 5, 页码 3763-3773出版社
SPRINGER
DOI: 10.1007/s13277-014-3017-3
关键词
miR-221/222; TIMP2; Gliomas; Invasion and metastasis; Angiogenesis
类别
资金
- National Natural Sciences Foundation of China [81172289, 81472633]
miR-221/222 are two highly homologous microRNAs that are frequently upregulated in solid tumors. However, the effects of miR-221/222 in malignant gliomas have not been investigated thoroughly. In this study, we found that miR-221/222 were significantly upregulated in human glioma samples and glioma cell lines. Both gain- and loss-of-function studies showed that miR-221/222 regulate cell proliferation, the cell cycle and apoptosis, in addition to, invasion, metastasis, and angiogenesis in glioma cell lines. Subsequent investigations revealed that TIMP2 is a direct target of miR-221/222, and overexpression of TIMP2 reduced the miR-221/222-mediated invasion, metastasis, and angiogenesis of glioma cells. Taken together, our results suggest that the suppression of miR-221/222 may be a feasible approach for inhibiting the malignant behaviors of glioma.
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