期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 117, 期 -, 页码 34-39出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2013.12.002
关键词
Morphine; Glucose; Antinociception; Rats
资金
- Individual National Research Service Award from the National Institutes on Drug Abuse at the National Institutes of Health [5F31 DA15258]
- National Institutes on Drug Abuse [DA02132]
The effects of intraperitoneal (ip) D-glucose administration on antinociception were studied in male Long-Evans rats. Rats were assessed for antinociception using the hot-water tail-withdrawal procedure (54 +/- 0.2 degrees C) to determine if peripheral administration of D-glucose (300, 560, or 720 mg/kg) would enhance morphine-mediated antinociception (MMA) (1.0, 3.0, 42, 5.6, and 10.0 mg/kg cumulative-dosing regime) and if D-glucose (560, 720, or 1000 mg/kg) alone could produce antinociceptive activity that was naloxone (0.32 mg/kg) reversible. Additionally, the actions of D-glucose on MMA were compared with a stereoisomer, L-glucose, which is not metabolized. The results of these studies demonstrate that peripheral administration of D-glucose significantly enhances MMA and that D-glucose alone produces antinociceptive actions that are potentially mediated by the endogenous opioid system. Furthermore, L-glucose failed to have an effect on MMA suggesting that the alterations in antinociception seen with D-glucose are not due to stressors such as osmolality or injection. The current studies provide evidence that D-glucose alteration of antinociception is not simply a response to taste or gustation. (C) 2013 Elsevier Inc. All rights reserved.
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