期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 109, 期 -, 页码 84-90出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2013.05.007
关键词
Hormonal contraception; Cortisol; Stress; Diurnal rhythm; Naltrexone; HPA axis
资金
- Department of Veterans Affairs
- National Institutes of Health, NIAAA [R01 AA12207]
- National Institutes of Health, NIRR [M01 RR14467, UL1 RR025767, KL2 RR025766, RR025766]
- National Institutes of Health, NHLBI [F32 HL083689]
The use of hormonal contraception (HC) may affect salivary cortisol levels at rest and in response to a pharmacological or stress challenge. Therefore, the current study used a secondary data analysis to investigate the effect of HC on salivary cortisol levels in response to the mu-opioid receptor antagonist naltrexone and a psychosocial stressor, and also across the diurnal curve. Two hundred and nine women (n = 72 using hormonal contraception; HC+) completed a two-session stress response study that consisted of a stress day, in which they were exposed to public speaking and mental arithmetic, and a rest day, in which unstimulated cortisol levels were measured to assess the diurnal rhythm. A subset of seventy women (n = 24 HC+) also completed a second study in which they were administered oral naltrexone (50 mg) or placebo in a randomized, placebo-controlled, double blind fashion. Women who were HC + had a significantly reduced salivary cortisol response to both the psychosocial stressor (p < 0.001) and naltrexone (p<0.05) compared to HC- women. Additionally, HC+ women had a significantly altered morning diurnal cortisol rhythm (p<0.01), with a delayed peak and higher overall levels. The results of the current study confirm that HC attenuates salivary cortisol response to a psychosocial stressor and mu-opioid receptor antagonism, and also alters the morning diurnal cortisol curve. Published by Elsevier Inc.
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