期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 114, 期 -, 页码 58-63出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2013.10.019
关键词
Neuropathic pain; Chronic constriction injury; Opioid receptor; Nitric oxide; Cyclic guanosine monophosphate; ATP-sensitive potassium channel
资金
- Faculty of Medicine and Health Sciences and Institute of Bioscience, Universiti Putra Malaysia
- Research University Grant Scheme from the Universiti Putra Malaysia [04-01-11-1177RU]
- Malaysian Toray Science Foundation [MTSF 11/09]
The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using Randall-Selitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blacker), nor-binaltorphimine (nor-BNI, selective kappa-opioid receptor blacker), but not beta-funaltrexamine (beta-FN, selective mu-opioid receptor blacker) and naltrindole hydrochloride (NTI, selective delta-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a] quinoxalin-l-one (ODQ soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blacker) but not N omega-nitro-L-arginine L-NAME, a nitric oxide synthase blacker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include kappa-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening. (C) 2013 Elsevier Inc. All rights reserved.
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