期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 95, 期 3, 页码 325-330出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2010.02.008
关键词
Lecozotan; 5-HT1A; Memory; Anxiety; Behavioral depression; Alzheimer's disease
资金
- Consejo de Desarrollo Cientifico
- Humanistic y Tecnologico of Universidad Centroccidental Lisandro Alvarado
- Universidad de los Andes (CDCHT-UCLA) [022-ME-2007, M-824-05-03-A]
Lecozotan is a selective serotonergic 5-HT1A receptor antagonist previously shown to enhance task performance efficiency in aged rhesus monkeys. In the present report we tested the ability of this drug to modify memory and learning in rats during a modified passive avoidance response test, and also tested its effect on anxiety with the elevated plus maze, and behavioral depression in the inescapable swim test. Lecozotan enhanced memory in a dose-dependent manner (0, 0.3, 0.5, 1 and 2 mg/kg; s.c.), or prevented memory impairment previously induced with scopolamine-HCl. No significant changes in anxiety and behavioral depression were detected in animals treated with different doses of lecozotan (0, 0.3, 1 and 2 mg/kg; s.c.) compared to control animals. These results suggest that lecozotan could enhance learning and memory in animals without affecting anxiety or behavioral depression scores and that it could be a viable alternative in the treatment of patients with cognitive deficits such as the Alzheimer's disease. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据