期刊
TUMOR BIOLOGY
卷 37, 期 5, 页码 6073-6084出版社
SPRINGER
DOI: 10.1007/s13277-015-4442-7
关键词
CD24; Epithelial-mesenchymal transition; Hepatocellular carcinoma; Notch1; Tumor immunity
类别
资金
- National Natural Science Foundation [30901750, 81272322]
- Jiangsu science and technology innovation Program for graduate Research Funds [CXLX13-54]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Qing Lan Project
- Six talent peaks project of Jiangsu Province [JY-018]
CD24 is known as a cell surface molecule in hematopoiesis and also described as a diagnostic marker for tumors. Previous studies suggested the important role of CD24 in hepatocellular carcinoma (HCC) pathogenesis. However, precise functions of CD24 in HCC are still unknown. Here, we found that CD24 is highly expressed in HCC both in mRNA and protein levels. Further, the epithelial-mesenchymal transition (EMT) and Notch1 signaling activations mediated by CD24 were elucidated as potential mechanisms of HCC promotion in Hepa1-6/ Hepa1-6-CD24 cell models. Additionally, possible systemic immune reaction was explored through immune cells and Hepa1-6/ Hepa1-6-CD24 cell co-culture. We demonstrated that the EMT process of HCC cell was effectively induced by CD24; also, the tumor immune microenvironment was changed by facilitating Notch-related EMT in vivo. These results reveal the underlying link between the HCC processes mediated by CD24. Moreover, as a clear tumor promoter, CD24 is considered a potential new target for HCC treatment.
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