期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 96, 期 3, 页码 260-265出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2010.05.014
关键词
Salvia divinorum; Salvinorin A; Kappa opioid receptors; LSD; Ketamine; Drug discrimination; Rats
资金
- Graduate College at Western Michigan University
- Mailman Research Center, McLean Hospital, Belmont, MA
Salvia divinorum is a small perennial shrub that has gained recent popularity among the drug-using subculture as a legal alternative to hallucinogens. Salvinorin A. the main active compound found in the S divinorum plant, is an atypical hallucinogen with pharmacological selectivity at kappa opioid (KOP) receptor sites and is a unique non-nitrogenous neoclerodane diterpene which is structurally distinct from other opioid compounds. The novel structure of salvinorin A and its specific binding affinity to KOP receptors provide a unique opportunity to investigate neurochemical mechanisms of hallucination and hallucinogenic compounds The current investigation assessed the substitution of salvinorin A in 16 male Sprague-Dawley rats trained to discriminate either the prototypical serotonergic hallucinogen, LSD (0 08 mg/kg, SC. n = 8) or the dissociative anesthetic and glutamatergic hallucinogen. ketamine (8 0 mg/kg, IP., n = 8) from vehicle under a FR 20 schedule of food-reinforced responding. Results indicated that neither LSD nor ketamine discrimination generalized to salvinorin A These findings are consistent with the growing body of evidence that salvinorin A is pharmacologically distinct from other traditional hallucinogenic compounds (C) 2010 Elsevier Inc All rights reserved
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