期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 93, 期 4, 页码 406-412出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2009.06.002
关键词
Anxiety; Defensive burying test; Estradiol; Formestane; Tamoxifen; Testosterone
资金
- Consejo Nacional de Ciencia y Tecnologia, Mexico [CB-2006-1, 61741]
- Sistema Nacional de Investigadores [32755, 754]
Testosterone exerts anxiolytic effects, but the participation of its aromatase metabolic product estradiol is controversial. Therefore, we used the defensive burying paradigm in female Wistar rats to explore testosterone's (1.0 mg/rat, s.c.) interactions with picrotoxin (a noncompetitive gamma-aminobutyric acid-A receptor [GABA(A)] antagonist; 1.0 mg/kg, i.p.), formestane (an aromatase inhibitor; 3.0 mg/rat, s.c.), and tamoxifen (an estrogen receptor-beta antagonist; 1.0 mg/kg, s.c.). Serum levels of testosterone, estradiol, and progesterone were determined in the same rats. Burying latency and locomotion did not significantly change. Systemic testosterone administration enhanced serum testosterone and estradiol levels and reduced defensive burying. This reduction in total burying was blocked by pretreatment with picrotoxin and tamoxifen, but not formestane. We conclude that testosterone produced anxiolytic-like effects in female rats that were mediated by actions at the GABA(A) receptor. with participation of the estradiol receptor-beta, rather than estradiol aromatization. Published by Elsevier Inc.
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